Virus-friendly Th17s
نویسندگان
چکیده
منابع مشابه
Virus-friendly Th17s
Gfi-1 also dampens the cells’ tendencies toward the Th17 and T reg cell lineages. Gfi-1 inhibited production of IL-17 and blocked the expression of CD103, which is found on certain T reg cells. In a model of autoimmunity, mice that lacked Gfi-1 developed a preponderance of CD103expressing T reg cells, thus delaying the onset of disease. The protein prevented gene expression by binding to loci i...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2009
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2062iti4